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Mobile Phase Modulator Langmuir¶
This model is a modified Langmuir model (see Section Multi Component Langmuir) which can be used to describe hydrophobic interaction chromatography [17, 18]. A modulator component (termed “salt”, \(c_{p,0}\) and \(q_0\)) influences ad- and desorption processes:
where \(c_{p,0}\) and \(q_0\) denote the salt concentrations in the liquid and solid phase of the beads respectively. Salt is considered to be inert, therefore either
is used if salt has one bound state, or salt can be used without a bound state. The parameter \(\gamma\) describes the hydrophobicity and \(\beta\) the ion-exchange characteristics.
For more information on model parameters required to define in CADET file format, see Mobile Phase Modulator Langmuir.